Withdrawal from chronic use of high doses of marijuana cause headache, shakiness, sweating, and stomach pains and nausea. Withdrawal symptoms also include behavioral signs such as:  Restlessness, irritability, sleep difficulties, and decreased appetite

Barbiturates are abused by swallowing a pill or injecting a liquid form. Barbiturates can be extremely dangerous because overdoses can occur easily and lead to death.

Prescribed as Adderall®, Concerta®, Dexedrine®, Focalin®, Metadate®, Methylin®, Ritalin®.

Meth is swallowed, snorted, injected, or smoked. Meth is a highly addictive drug with potent central nervous system (CNS) stimulant properties.

One of the most significant effects of heroin use is addiction. As higher doses of the drug are used over time, physical dependence and addiction to the drug develop. 

Benzodiazepines abuse is frequently associated with  teens and young adults who take the drug orally or crush it up and snort it to get high. Abuse is particularly high among heroin and cocaine users. 

DEA officials report a dramatic rise in the number of counterfeit pills containing at least 2 mg of fentanyl, which is considered a deadly dose. Fentanyl, the synthetic opioid most commonly found in counterfeit pills, is the primary driver in this alarming increase in overdose deaths.

Cocaine/Crack is an intense, euphoria-producing stimulant drug with strong addictive potential. 

Abuse is often associated with a pattern of
binge use — sporadically consuming large doses
of stimulants over a short period of time. Heavy
users of often experience delirium, psychosis,
and physical exhaustion.